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1

From in silico target prediction to multi-target drug design: Current databases, methods and applications

Alexios Koutsoukas, Benjamin Simms, Johannes Kirchmair, Peter J. Bond, Alan V. Whitmore, Steven Zimmer, Malcolm P. Young, Jeremy L. Jenkins, Meir Glick, Robert C. Glen, Andreas Bender

Journal:

Journal of Proteomics

Year:

2011

Language:

english

File:

PDF, 1.29 MB

english, 2011

2

Biomarkers of Aging: From Cellular Senescence to Age-Associated Diseases

Martins, Maria João, Constância, Miguel, Neves, Delminda, Simm, Andreas

Journal:

Oxidative Medicine & Cellular Longevity

Year:

2017

Language:

english

File:

PDF, 1.26 MB

english, 2017

3

Altern und ErnÃ¤hrung; Aging and nutrition;

Klotz, Lars-Oliver, Simm, Andreas

Journal:

Zeitschrift für Gerontologie und Geriatrie

Year:

2020

File:

PDF, 327 KB

2020

4

Stress: the good, the bad and the ugly?

Gogol, Manfred, Simm, Andreas

Journal:

Zeitschrift für Gerontologie und Geriatrie

Year:

2015

Language:

english

File:

PDF, 107 KB

english, 2015

5

Glyoxalase 1 expression is downregulated in preimplantation blastocysts of diabetic rabbits

Seeling, Tom, Haucke, Elisa, Navarrete Santos, Alexander, Grybel, Katarzyna J., Gürke, Jacqueline, Pendzialek, S. Mareike, Schindler, Maria, Simm, Andreas, Navarrete Santos, Anne

Journal:

Reproduction in Domestic Animals

Year:

2019

Language:

english

File:

PDF, 848 KB

english, 2019

6

Carbohydrates in nutrition: friend or foe?; Kohlenhydrate in der ErnÃ¤hrung: Freund oder Feind?;

GroÃkopf, Anne, Simm, Andreas

Journal:

Zeitschrift für Gerontologie und Geriatrie

Year:

2020

File:

PDF, 359 KB

2020

7

Platelet-derived growth factor isoforms prevent cell death during starvation of AKR-2B fibroblasts

Andreas Simm, Viviane Hoppe, Jürgen Hoppe, Aviv Gazit

Journal:

Journal of Cellular Physiology

Year:

1994

Language:

english

File:

PDF, 862 KB

english, 1994

8

Differential activation by platelet-derived growth factor-BB of mitogen activated protein kinases in starved or nonstarved AKR-2B fibroblasts

Jürgen Hoppe, Viviane Hoppe, Thomas-Andreas Karenberg, Anke Fenn, Andreas Simm, Agapios Sachinidis

Journal:

Journal of Cellular Physiology

Year:

1994

Language:

english

File:

PDF, 1.01 MB

english, 1994

9

Maillard reaction products enriched food extract reduce the expression of myofibroblast phenotype markers

Stefanie Ruhs, Norbert Nass, Veronika Somoza, Ulrich Friess, Reinhard Schinzel, Rolf-Edgar Silber, Andreas Simm

Journal:

Molecular Nutrition & Food Research

Year:

2007

Language:

english

File:

PDF, 525 KB

english, 2007

10

Lung level of HMBG1 is elevated in response to advanced glycation end product-enriched food in vivo

Babett Bartling, Christine Fuchs, Veronika Somoza, Bernd Niemann, Rolf-Edgar Silber, Andreas Simm

Journal:

Molecular Nutrition & Food Research

Year:

2007

Language:

english

File:

PDF, 1.48 MB

english, 2007

11

Book News: Nutritional Genomics – Impact on Health and Disease. Edited by Regina Brigelius-Flohé and Hans-Georg Joost

Journal:

Molecular Nutrition & Food Research

Year:

2007

Language:

english

File:

PDF, 586 KB

english, 2007

12

Determination of Copy Number of c-Myc Protein per Cell by Quantitative Western Blotting

Claudia Rudolph, Gerold Adam, Andreas Simm

Journal:

Analytical Biochemistry

Year:

1999

Language:

english

File:

PDF, 139 KB

english, 1999

13

Mesangial cell hypertrophy induced by NH4Cl: Role of depressed activities of cathepsins due to elevated lysosomal pH

Ling, Hong, Ardjomand, Pyam, Samvakas, Spiro, Simm, Andreas, Busch, Gillian L., Lang, Florian, Sebekova, Katarina, Heidland, August

Journal:

Kidney International

Year:

1998

Language:

english

File:

PDF, 362 KB

english, 1998

14

Advanced glycation end products impair protein turnover in LLC-PK1: Amelioration by trypsin

Xiang, Guangsheng, Schinzel, Reinhard, Simm, Andreas, Sebekova, Katarina, Heidland, August

Journal:

Kidney International

Year:

2001

File:

PDF, 849 KB

2001

15

Reactive oxygen species (ROS) and aging: Do we need them — can we measure them — should we block them?

Andreas Simm, Hans-Jürgen Brömme

Journal:

Signal Transduction

Year:

2005

Language:

english

File:

PDF, 112 KB

english, 2005

16

Maillard reaction product-rich food impair cell proliferation and induce cell death in vitro

Babett Bartling, Grit Rehbein, Veronika Somoza, Rolf-Edgar Silber, Andreas Simm

Journal:

Signal Transduction

Year:

2005

Language:

english

File:

PDF, 287 KB

english, 2005

17

Editorial

Andreas Simm, Ralf Hass

Journal:

Signal Transduction

Year:

2005

Language:

english

File:

PDF, 19 KB

english, 2005

18

Insulin fails to modulate the cardiac L-Type Ca2+ current in Type II diabetes patients – a possible link to cardiac dysfunction in diabetes mellitus

Sebastian Maier, Volkmar Lange, Andreas Simm, Ulrich Walter, Michael Kirstein

Journal:

Year:

2001

Language:

english

File:

PDF, 30 KB

english, 2001

19

A positive inotropic effect of adenosine in cardiac preparations of right atria from diseased human hearts

Ulrich Gergs, Peter Boknik, Wilhelm Schmitz, Andreas Simm, Rolf-Edgar Silber, Joachim Neumann

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

2009

Language:

english

File:

PDF, 236 KB

english, 2009

20

Phosphorylation of phospholamban and troponin I through 5-HT4receptors in the isolated human atrium

Ulrich Gergs, Joachim Neumann, Andreas Simm, Rolf-Edgar Silber, Freerk Ole Remmers, Stephanie Läer

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

2009

Language:

english

File:

PDF, 284 KB

english, 2009

21

Inotropic effects ofl-lysine in the mammalian heart

Andreas Boldt, Ulrich Gergs, Julia Frenker, Andreas Simm, Rolf-Edgar Silber, Udo Klöckner, Joachim Neumann

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

2009

Language:

english

File:

PDF, 220 KB

english, 2009

22

Production and characterisation of a C595 antibody-99mTc conjugate for immunoscintigraphy of bladder cancer

Matthew S. Simms, Andrea Murray, Graeme Denton, David P. Scholfield, Michael R. Price, Alan C. Perkins, Michael C. Bishop

Journal:

Year:

2001

Language:

english

File:

PDF, 353 KB

english, 2001

23

Density dependent expression of PDGF-A modulates the angiotensin II dependent proliferation of rat cardiac fibroblasts

Andreas Simm, Claudius Diez

Journal:

Basic Research in Cardiology

Year:

1999

Language:

english

File:

PDF, 178 KB

english, 1999

24

VASP-dependent regulation of actin cytoskeleton rigidity, cell adhesion, and detachment

Annette B. Galler, Maísa I. García Arguinzonis, Werner Baumgartner, Monika Kuhn, Albert Smolenski, Andreas Simm, Matthias Reinhard

Journal:

Histochemistry and Cell Biology

Year:

2006

Language:

english

File:

PDF, 1.15 MB

english, 2006

25

Infection of dendritic cells by enterobacteriaceae

Michael Schoppet, Hans-Iko Huppertz, Andreas Simm, Andreas Bubert

Journal:

Medical Microbiology and Immunology

Year:

2000

Language:

english

File:

PDF, 280 KB

english, 2000

26

Expression of inhibitors of apoptosis (IAP) proteins in non-small cell human lung cancer

Hans-Stefan Hofmann, Andreas Simm, Andreas Hammer, Rolf-Edgar Silber, Babett Bartling

Journal:

Journal of Cancer Research and Clinical Oncology

Year:

2002

Language:

english

File:

PDF, 285 KB

english, 2002

27

Age-dependent increase of prolyl-4-hydroxylase domain (PHD) 3 expression in human and mouse heart

Susanne Rohrbach, Andreas Simm, Reinhard Pregla, Corinna Franke, Dörthe M. Katschinski

Journal:

Year:

2005

Language:

english

File:

PDF, 226 KB

english, 2005

28

Delivery of antigen-encoding plasmid DNA into the cytosol of macrophages by attenuated suicide Listeria monocytogenes

Dietrich, Guido, Bubert, Andreas, Gentschev, Ivaylo, Sokolovic, Zeljka, Simm, Andreas, Catic, Andre, Kaufmann, Stefan H.E., Hess, Jürgen, Szalay, Aladar A., Goebel, Werner

Journal:

Nature Biotechnology

Year:

1998

File:

PDF, 612 KB

1998

29

Cardiovascular anomalies in children and young adults with Ullrich-Turner syndrome—the erlangen experience

Thomas M. K. Völkl, Karin Degenhardt, Andreas Koch, Diemud Simm, Helmuth G. Dörr, Professor Helmut Singer

Journal:

Clinical Cardiology

Year:

2005

Language:

english

File:

PDF, 42 KB

english, 2005

30

Depression of progenitor cell function by advanced glycation endproducts (AGEs): Potential relevance for impaired angiogenesis in advanced age and diabetes

Robert J. Scheubel, Simone Kahrstedt, Holger Weber, Juergen Holtz, Ivar Friedrich, Jochen Borgermann, Rolf-Edgar Silber, Andreas Simm

Journal:

Experimental Gerontology

Year:

2006

Language:

english

File:

PDF, 248 KB

english, 2006

31

Cardiovascular ageing: A crosstalk between basic science and clinical practise is needed!

Journal:

Experimental Gerontology

Year:

2006

Language:

english

File:

PDF, 45 KB

english, 2006

32

Senescent fibroblasts induce moderate stress in lung epithelial cells in vitro

Babett Bartling, Grit Rehbein, Rolf-Edgar Silber, Andreas Simm

Journal:

Experimental Gerontology

Year:

2006

Language:

english

File:

PDF, 240 KB

english, 2006

33

DCFH2 interactions with hydroxyl radicals and other oxidants – Influence of organic solvents

Hans-Jürgen Brömme, Leoni Zühlke, Rolf-Edgar Silber, Andreas Simm

Journal:

Experimental Gerontology

Year:

2008

Language:

english

File:

PDF, 1.06 MB

english, 2008

34

Tissue ageing: Do insights into molecular mechanisms of ageing lead to new therapeutic strategies?

Andreas Simm, Thomas A. Rando

Journal:

Experimental Gerontology

Year:

2008

Language:

english

File:

PDF, 120 KB

english, 2008

35

Age dependency of the cariporide-mediated cardio-protection after simulated ischemia in isolated human atrial heart muscles

Andreas Simm, Ivar Friedrich, Robert J. Scheubel, Torsten Gursinsky, Rolf-Edgar Silber, Babett Bartling

Journal:

Experimental Gerontology

Year:

2008

Language:

english

File:

PDF, 295 KB

english, 2008

36

Evidences for age-related modulation of human hematopoietic progenitor cell proliferation

Alexander Navarrete Santos, Simone Kahrstedt, Norbert Nass, Elke Czeslick, Robert J. Scheubel, Rolf-Edgar Silber, Andreas Simm

Journal:

Experimental Gerontology

Year:

2008

Language:

english

File:

PDF, 386 KB

english, 2008

37

Biomarkers of ageing: A challenge for the future

Andreas Simm, Thomas E. Johnson

Journal:

Experimental Gerontology

Year:

2010

Language:

english

File:

PDF, 117 KB

english, 2010

38

Preconditioning with Maillard reaction products improves antioxidant defence leading to increased stress tolerance in cardiac cells

Stefanie Ruhs, Norbert Nass, Babett Bartling, Hans-Jürgen Brömme, Beatrice Leuner, Veronika Somoza, Ulrich Friess, Rolf-Edgar Silber, Andreas Simm

Journal:

Experimental Gerontology

Year:

2010

Language:

english

File:

PDF, 754 KB

english, 2010

39

Corrigendum to “Preconditioning with Maillard reaction products improves antioxidant defence leading to increased stress tolerance in cardiac cells” [Experimental Gerontology 45/10 (2010) 752–762]

Stefanie Ruhs, Norbert Nass, Babett Bartling, Hans-Jürgen Brömme, Beatrice Leuner, Veronika Somoza, Ulrich Friess, Rolf-Edgar Silber, Andreas Simm

Journal:

Experimental Gerontology

Year:

2011

Language:

english

File:

PDF, 97 KB

english, 2011

40

Bone marrow cells and CD117-positive haematopoietic stem cells promote corneal wound healing

Saadettin Sel, Ulf M. Schilling, Norbert Nass, Andreas Simm, Fabian Garreis, Matthias Knak, Joachim Storsberg, Maja Kaiser, Thomas Kalinski, Dirk Ehrich, Timm Bredehorn-Mayr, Friedrich Paulsen

Journal:

Acta Ophthalmologica (Blackwell)

Year:

2012

Language:

english

File:

PDF, 452 KB

english, 2012

41

Genomic scan for quantitative trait loci of chemical and physical body composition and deposition on pig chromosome X including the pseudoautosomal region of males

Carol-Anne Duthie, Geoff Simm, Miguel Pérez-Enciso, Andrea Doeschl-Wilson, Ernst Kalm, Pieter W Knap, Rainer Roehe

Journal:

Genetics Selection Evolution

Year:

2009

Language:

english

File:

PDF, 597 KB

english, 2009

42

Okadaic Acid Blocks PDGF-Induced Proliferation of AKR-2B Fibroblasts at the Transition from G1- to S-Phase

Andreas Simm, Thomas-Andreas Karenberg, Viviane Hoppe, Jürgen Hoppe

Journal:

Experimental Cell Research

Year:

1994

File:

PDF, 361 KB

1994

43

Late Signals from the PDGF Receptors Leading to the Activation of the p70S6-Kinase Are Necessary for the Transition from G1 to S phase in AKR-2B Cells

Andreas Simm, Viviane Hoppe, Doris Karbach, Monika Leicht, Anke Fenn, Jürgen Hoppe

Journal:

Experimental Cell Research

Year:

1998

Language:

english

File:

PDF, 1.38 MB

english, 1998

44

PDGF-AA, a Potent Mitogen for Cardiac Fibroblasts from Adult Rats

Andreas Simm, Matthias Nestler, Viviane Hoppe

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1997

Language:

english

File:

PDF, 616 KB

english, 1997

45

Level of ribosomal RNA required for stimulation from quiescence increases during cellular aging in vitro of mammalian fibroblasts

Gerold Adam, Andreas Simm, Friedlinde Braun

Journal:

Experimental Cell Research

Year:

1987

Language:

english

File:

PDF, 887 KB

english, 1987

46

PDGF-AA effectively stimulates early events but has no mitogenic activity in AKR-2B mouse fibroblasts

Andreas Simm, Viviane Hoppe, Dieter Tatje, Anja Schenzinger, Jürgen Hoppe

Journal:

Experimental Cell Research

Year:

1992

Language:

english

File:

PDF, 3.63 MB

english, 1992

47

Glycation of PDGF results in decreased biological activity

Norbert Nass, Katrin Vogel, Britt Hofmann, Peter Presek, Rolf-Edgar Silber, Andreas Simm

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2010

Language:

english

File:

PDF, 617 KB

english, 2010

48

PS1-069 In vitro microdialysis of cytokines applying a validated cba/facs quantification method

Claudia Kirbs, Andreas Simm, Charlotte Kloft

Journal:

Year:

2011

Language:

english

File:

PDF, 45 KB

english, 2011

49

S100A2–S100P expression profile and diagnosis of non-small cell lung carcinoma: Impairment by advanced tumour stages and neoadjuvant chemotherapy

Babett Bartling, Grit Rehbein, Wolfgang Daniel Schmitt, Hans-Stefan Hofmann, Rolf-Edgar Silber, Andreas Simm

Journal:

European Journal of Cancer

Year:

2007

Language:

english

File:

PDF, 822 KB

english, 2007

50

Paracrine effects of CD34 progenitor cells on angiogenic endothelial sprouting

Robert J. Scheubel, Juergen Holtz, Ivar Friedrich, Jochen Borgermann, Simone Kahrstedt, Alexander Navarrete Santos, Rolf-Edgar Silber, Andreas Simm

Journal:

International Journal of Cardiology

Year:

2010

Language:

english

File:

PDF, 336 KB

english, 2010

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